Juxtaglomerular apparatus
The juxtaglomerular apparatus (JGA), also referred to as the juxtaglomerular complex, is a specialized region of the nephron formed by three different types of cells: macula densa, juxtaglomerular granular, and extraglomerular mesangial (Lacis) cells. The tightly packed macula densa is situated at the transition between the ascending limb of the nephron loop and the distal tubule, where it comes into contact with the juxtaglomerular granular cells, which are modified smooth muscle cells in the afferent (and sometimes efferent) arteriole. Enclosed in the triangular space between the afferent and efferent arteriole and the macula densa of the distal tubule are the extraglomerular mesangial cells.
The JGA functions to regulate systemic blood pressure and glomerular blood flow and filtration rate.
Terminology |
English: Juxtaglomerular aparatus Latin: Complexus juxtaglomerularis |
Definition | Region of the nephron formed by the macula densa, juxtoglomerular granular cells and extraglomerular mesangial cells |
Function | Regulates blood pressure and glomerular filtration rate |
Learn more about the histology of the kidneys with this study unit (and article):
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